Scientific communications

Mixed Lymphocyte Reaction for novel cancer immunotherapy testing

10 / 18 / 2018

The immunological synapse that occurs between T lymphocytes and Dendritic cells (DCs) is a key component of an effective immune response and is controlled by a combination of stimulatory and inhibitory signals – also called immune checkpoints. As to trigger a better anti-tumor immune response, interventions through a fine-tuning of these control signals within the immunological synapse represent one of the most promising cancer immunotherapy strategies.

Quantitative in vitro assays for pharmacological characterization of PD1/PDL1 and CTLA4 immune checkpoint blockade

09 / 19 / 2018

Activation of T cell immune response through regulation of immune checkpoint pathways is one of the most considerable strategies being employed in cancer immunotherapy, either as individual or in combination. While development of checkpoint inhibitors blocking PD1/PDL1 interaction is still a major interest thereby contributing to the suppression of tumor immune resistance, accurate identification and robust pharmacological characterization of modulatory agents thus become key and should be guaranteed through the assays.

New In Vivo Syngeneic Glioblastoma Mouse Model – Shuttle Session

05 / 23 / 2018

To get the opportunity to cost-effectively assess your drug candidates in our well-suited immunocompetent syngeneic model, do not miss our new in vivo glioblastoma shuttle session by mid-June, 2018. In this session, only experimental test groups-related costs will be covered by Sponsors ; control groups being supported by Explicyte.

New In Vivo Syngeneic Mammary Fat Pad Mouse Model Shuttle Session

02 / 28 / 2018

In view of the success of our previous shuttle sessions, which offered the opportunity to run efficacy studies in a cost-saving manner, we are planning a new shuttle on the orthotopic (OT) 4T1 mammary fat pad mouse model, which will be held in late March.

In Vitro Immune Cell Activation

02 / 19 / 2018

Modulation of the immune system function aiming at enhancing the responsiveness potential of immune cells is one of the current promising challenges in cancer immunotherapy. Upon activation, immune (T) cells undergo clonal expansion followed by differentiation into effectors to mediate cytotoxicity and/or cytokine release. Modulating the mechanisms underlying immune cell activation is key for the development of innovative approaches to promote immune function and tackle tumor progression.

Combination Of In Vivo Efficacy Monitoring With Intratumoral Biopsy To Assess New Cancer Therapies & Decipher Their MoA

01 / 24 / 2018

Immunosuppressive Tumor Microenvironment In OT 4T1 Breast Tumor Model

10 / 16 / 2017

While known and validated as non-responsive to conventional immune checkpoint inhibitors, our OT syngeneic mammary tumor model, which represents an aggressive model of human breast carcinoma, is characterized by the presence of at least two types of tumor-infiltrating immunosuppressive cells – myeloid suppressive cells (MSC) and T regulatory cells (Treg). Such cell populations are known, as a result, to suppress effector immune cell responses, thereby promoting tumor immune escape and metastasis.

New In Vivo Syngeneic Subcutaneous CT26 Colon Tumor Model Shuttle Session

09 / 07 / 2017

Because of the success of previous shuttle sessions, which offered the opportunity to run efficacy studies in a cost-saving manner, Explicyte is planning a new shuttle on the CT26 tumor-bearing mouse model, which will take place in October.

Orthotopic GL261 Glioma Mouse Model To Test Your Immunomodulatory Compound

07 / 07 / 2017

In vivo glioma mouse model recapitulating key human glioblastoma characteristics provide an invaluable resource to assess novel immunotherapy-based strategies aiming at bolstering immune system functions to ultimately improve treatment outcome.

In Vivo Syngeneic Subcutaneous CT26 Colon Tumor Model Shuttle Session

06 / 14 / 2017

As in the previous shuttle session, Explicyte will plan a new shuttle on the CT26 tumor-bearing mouse model, which will be held in July.