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A syngeneic renal cancer mouse model for the discovery of novel immuno-oncology therapies

11 / 18 / 2020

A syngeneic renal cancer mouse model for the discovery of novel immuno-oncology therapies

We have fully set up and characterized a syngeneic Renca renal mouse model recapitulating most of the human RCC condition features. Indeed, our model displays an enriched tumor microvascular environment and relatively low immune infiltration - nevertheless constituted of a strong Myeloid-Derived Suppressor Cells (MDSCs) proportion.

 

A syngeneic orthotopic EMT6 breast mouse model for preclinical immuno-oncology testing of novel anti-cancer strategies

07 / 09 / 2020

A syngeneic orthotopic EMT6 breast mouse model for preclinical immuno-oncology testing of novel anti-cancer strategies

Because of metastatic development of the disease, among other characteristics, and regardless of survival data, breast cancer was shown to be particularly difficult to treat. However, metastases as well as resistance to therapies continue to be a great challenge and the development of new therapeutic strategies is increasingly necessary.