Our in vitro services at a glance

in vitro services CRO immuno-oncology cancer immunotherapy screening

10 years of experience testing novel anti-cancer immunotherapies

  • New chemical entities (NCEs)
  • Biologics: immune checkpoint inhibitors, bispecific T-cell engagers, ADCs
  • Cancer vaccines: Gene & RNA therapies, oncolytic viruses
  • Cell therapies: CAR-Ts, NKs
in vitro human cancer models immuno oncology screening CRO service

Custom human in vitro tumor models to assess immune response

  • >Over 100 cancer cell lines to model any malignancy, including tumors that are non-responsive to standard immunotherapies
  • Co-cultures with primary immune cells to recapitulate the immunological synapse (Ts, NKs, macrophages, dendritic cells, etc.)
in vitro screening platforms immuno-oncology

A flexible platform for screening & mechanism of action studies

  • Live cell imaging to track immune cell activation, expansion & tumor-killing activity
  • Flow cytometry for multiplexed immuno-phenotyping
  • Cytokine analysis, proteomics, and transcriptomics to document immune response

Why working with Explicyte?

Experts
in Immuno-Oncology

  • 100+ in vitro campaigns conducted over the past 10 years
  • 20+ peer-reviewed publications in key immuno-oncology journals

Personalized
approach

  • Targeted discussion based on request to design bespoke strategy & fit-for-purpose study proposal
  • A dedicated study director (PhD level) from experimental plan to final report discussion
  • Custom assays: cellular model, readouts & reference treatment defined with the sponsor

Your contacts

explicyte team 2024

Talk to our team !

Study directors: Paul Marteau, PharmD (not on picture), Jean-Philippe Guégan, PhD Leadership: Imane Nafia, PhD (CSO), Alban Bessede, PhD (founder, CEO), Loic Cerf, MSc (COO)

Tell us about your project !

    Select department:

    Cell-based Assays for Immuno-Oncology I in vitro CRO Services I Cancer ImmunoTherapy screening

    Explicyte immuno-oncology is a preclinical CRO providing research services for the in vitro screening of novel cancer immunotherapies, including small molecules, monoclonal antibodies, BiTEs, ADCs, CAR-T cell therapies, and Natural Killer (NK) cell therapies. Our in vitro cancer models, co-cultured with immune cells, can be treated with immune checkpoint inhibitors, such as anti-PD-1/PDL-1 and CTLA-4 antibodies, for combinatorial strategies. Besides functional cellular assays to test the efficacy of anti-cancer immunotherapies, Explicyte offers a range of dedicated immuno-oncology assays for mechanism of action studies (MoA), such as cytokine release assays, immuno-phenotyping by FACS, and transcriptomic studies (RT-qPCR). Cancer immunotherapy strategies can be divided in three main categories including cytokines and immunomodulatory agents, antibody-based, and cell-based therapies. Explicyte’s expertise and advanced technologies have been harnessed so as to develop and build a cell-based service portfolio for immuno-oncology drug discovery. Our in vitro models & assays are sensitive, quantitative, and high throughput-compatible, thereby allowing to characterize and understand test compound’s effects, and identify single immunotherapeutic candidates or combination strategies that elicit immune cell functions and/or tumor cell sensitivity.

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