03 2021
M2 macrophage polarization assay for immunotherapeutics ...
Take advantage of new available seats on board or our upcoming shuttle session, ...Read more
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Get ready for the next in vitro shuttle session!M2 macrophage polarization assay
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Let’s start the Digital Spatial Profiling revolution together!NanoString GeoMx DSP, certified partner
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Quantitative histologyto feature the tumor immune contexture
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Cytokine release as relevant surrogatefor the immune cell subset function assessment on an in vitro platform of IO
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Featured ModelOrthotopic Glioblastoma Mouse Model
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Integrated Histology For Quantitative Digital PathologyHistology Services
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We test novel cancer immunotherapiesImmuno-oncology dedicated services
Preclinical services CRO for drug discovery
Explicyte Immuno-Oncology
We test novel drugs in validated in vitro and in vivo tumor models of cancer immunotherapies and analyze the anti-tumor immune response.
Explicyte immuno-oncology offers preclinical contract research services for cancer immunotherapy drug discovery. Our preclinical CRO services range from cell-based assays - for the phenotypic screening of novel immunotherapeutics and the in vitro determination of the molecular mechanism of action of new anti-cancer immune modulators - to in vivo studies, using syngeneic mouse tumor models treated with antitumor immunotherapies such as immune checkpoint inhibitors (anti CTLA-4 monoclonal antibodies, anti PD1/PDL-1 antibody therapy and IDO/TDO inhibitors). Furthermore, we offer to explore the in vivo mechanism of action of innovative immunotherapies such as anti-cancer vaccines through the profiling of the anti-tumor immune response by flow cytometry, high-content imaging and RT-qPCR. All our drug development services for cancer immunotherapy are performed in Bordeaux, France, serving clients all around the world.