mixed leukocyte reaction assay
Reference: SM0624
Contract type: Full time position, permanent contract
Location: Bordeaux, France

 

You are passionate about the interplay between immune and tumor cells? You have experience with 2D and 3D models? You master flow cytometry and other multiparametric platforms for in vitro analysis? The perspective of testing innovative cancer immunotherapies creates some excitement? Keep reading and apply!


Keep reading and apply!

 

About Explicyte


Explicyte is a preclinical and translational contract research organization specialized in immuno-oncology. Our goal is to assist academics, biotechs, and pharmas in the discovery of novel targets and novel cancer immunotherapies.

With a team of 25, we’re a human-sized company, which brings under the same roof cell biologists, immunologists, in vivo scientists, medical oncologists, and bioinformaticians. Focused on sponsors’ projects, our activity also involves in-house R&D and external collaborations, which led to the publication of 25+ papers in high-impact-factor journals.

Based in Bordeaux, our lab is located at the Bergonié Comprehensive Cancer Center, where we work in close contact with medical oncology teams. We believe Explicyte is a place to learn, grow, and have impact in the fight against cancer.

More about us

 

Your position


To strengthen and expand our in vitro team and activities, we are looking for an experienced in vitro Immuno-Oncology Scientist, ready to take up with us the setup of new in vitro platforms and assays, relevant for the testing and development of novel immunotherapeutic strategies.

In your role, you will be responsible for the technical and organizational management of sponsors’ and in-house R&D in vitro studies, from their implementation and performance to data analysis. You will timeously provide deliverables with respect to the project’s requirements and timelines.

You will interact closely with the in vitro team members, and will report to study directors and to the CSO.

What you will find at Explicyte

 

Your skills & traits



  • Ph.D - or equivalent - in science and health-related field

  • Minimum 2 years of experience in preclinical development in the health industry: Pharma, Biotech, CRO…

  • Broad understanding of tumor immunology and/or cancer therapies

  • Expertise in cell culture protocols (eg. 2D, 3D, immune/tumor cell co-cultures, immune cell isolation and cultivation, differentiation and polarization protocols)

  • Mastery of multiparametric analysis methodologies, mainly in flow cytometry

  • Project management experience (from planning to closing projects)

  • Excellent diligence

  • Strong interpersonal & organizational skills

  • Ability to easily adapt to changing priorities and challenges

  • Enthusiasm, curiosity, and integrity


 

Your missions & responsibilities



  • Provide draft protocols according to the proposed scientific and experimental strategies

  • Implement studies - relying on undeniable organizational skills - according to their design and established schedules

  • Manage and perform - diligently - in vitro and ex-vivo experiments

  • Cell culture-based experiments for functional immuno-oncology assays: with human and rodent cell origins, with tumor and/or immune cells (PBMCs, T cells, macrophages, tumor-infiltrating leukocytes…), and requiring immune cell isolation and cultivation, differentiation, polarization, etc

  • 3D approaches: spheroids, organoids, and patient-derived tumor samples and their use in preclinical research and therapeutic assessment

  • Ex vivo processing of collected samples for immune or tumor cell isolation, or for further analyses (FACS, ELISA…)

  • Capture, analyze and compile data, including quality controls

  • Ensure accuracy and completeness of study documentation and timely provide study deliverables

  • Write internal protocols and standard operating procedures

  • Contribute to experimental development by implementing new methods and training other collaborators and team’s members


 

Apply now! 


 

in vivo efficacy studies syngeneic tumor models CRO services
Reference: SM0524
Contract type: Full time position, permanent contract
Location: Bordeaux, France

 

You’re an accredited animal experimentalist with a passion for immune response mechanisms? You have experience with in vivo models for immuno-oncology? You master flow cytometry and other platforms for ex vivo analysis? The perspective of testing innovative cancer immunotherapies creates some excitement?


Keep reading and apply!

 

About Explicyte


Explicyte is a preclinical and translational contract research organization specialized in immuno-oncology. Our goal is to assist academics, biotechs, and pharmas in the discovery of novel targets and novel cancer immunotherapies.

With a team of 25, we’re a human-sized company, which brings under the same roof cell biologists, immunologists, in vivo scientists, medical oncologists, and bioinformaticians. Focused on sponsors’ projects, our activity also involves in-house R&D and external collaborations, which led to the publication of 25+ papers in high-impact-factor journals.

Based in Bordeaux, our lab is located at the Bergonié Comprehensive Cancer Center, where we work in close contact with medical oncology teams. We believe Explicyte is a place to learn, grow, and have impact in the fight against cancer.

More about us

 

Your position


To strengthen our in vivo preclinical activities, we are looking for an experienced in vivo Immuno-Oncology Study Manager, ready to take up with us the implementation of projects and their protocols, relevant for the testing and development of novel immunotherapeutic modalities.

In your role, you will be responsible for the technical and organizational management of sponsors’ and in-house R&D in vivo studies, from their implementation and performance to data analysis. You will timeously provide deliverables with respect to the project’s requirements and timelines.

You will closely interact with the in vivo team members. You will report to the Study Directors and CSO.

What you will find at Explicyte

 

Your skills & traits



  • Ph.D - or equivalent - in science and health-related field

  • •Accreditation in animal experimentation level 1/2 is mandatory, ethical standards and regulations

  • Deep knowledge and mastery of preclinical tumor-bearing mouse models

  • Expertise in tissue collection and processing for flow cytometry-based analysis

  • •Knowledge in the fields of tumor immunology and cancer therapies

  • •Minimum 1-2 years’ experience in in vivopreclinical development in a health industry: Pharma, Biotech, CRO…

  • Project management experience (from planning to closing projects)

  • Excellent diligence

  • Strong interpersonal & organizational skills

  • Ability to easily adapt to changing priorities and challenges

  • Enthusiasm, curiosity, and integrity


 

Your missions & responsibilities



  • Provide draft protocols according to the proposed scientific and experimental strategies

  • Implement studies - relying on undeniable organizational skills - according to their design and established schedules

  • Manage and perform - diligently - in vivo and ex vivo experiments

  • Tumor cell line culture and maintenance

  • Mastery of anesthesia and surgical gestures

  • Tumor cell inoculation (subcutaneous, intradermic, intracranial, mammary fat pad, intrasplenic, etc.)

  • In vivo monitoring: tumor growth (physical, bioluminescence), body weight and survival, tolerability evaluation

  • Mastery of neuro-oncology related in vivo protocols and models is a plus

  • Treatment administration (oral, intraperitoneal, intravenous, intratumoral)

  • Sampling of biological tissues (blood, tumor, lymph nodes, organs)

  • Ex vivo processing of collected samples for immune or tumor cell isolation, or for further analyses (FACS, ELISA…)

  • Capture, analyze and compile data, including quality controls

  • Ensure accuracy and completeness of study documentation and timely provide study deliverables

  • Write and submit animal referrals for ethical committee approval

  • Write internal protocols and standard operating procedures


 

Apply now! 


 

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