In Vivo Models For drug discovery

The growing interest of cancer therapy exploration requires more and more an increasing need for well-characterized preclinical in vivo models reliable for drug discovery. A more effective approach remains the use of syngeneic tumor-bearing mouse models – as surrogates for human cancer patients - which take advantage from xenograft tumors derived from the origin strains and inoculated into the mice to study how cancer therapies perform in the presence of a functional immunocompetent system.

To this end, Explicyte provides a series of syngeneic mouse models including subcutaneous and orthotopic models. These models are part of comprehensive offerings and serve as surrogates to investigate the anti-tumor response efficacy of exploratory cancer strategies as well as to delineate and profile the immune cell function underlying this anti-tumor response.