- Extensive coverage of the immune response, tissue microenvironment, tumor biology, and genes from clinically relevant genes sets such as tumor inflammation
- Spatial measurement of single cell signatures with high sensitivity and dynamic range
- Inclusion of genes for the Tumor Inflammation Signature, PAM50 and other clinical signatures
- Over 100 pathways to explore all aspects of cancer and tumor biology
The CTA assay is compatible with RNAscope® and antibody visualization markers. It can also be supplemented with up to 60 additional targets of interest.
Comprehensively Annotated Pathways in the CTA
Adaptive Immunity |
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Cell Function |
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Signaling Pathways |
T cells B cells |
Apoptosis |
AMPK Signaling |
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TCR & BCR Signaling |
Autophagy |
Androgen Signaling |
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Cancer Antigens |
Cell Adhesion & Motility |
EGFR Signaling |
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MHC Class I & II Antigen Presentation |
Cell Cycle |
ERBB2 Signaling |
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T-cell Checkpoints |
Cilium Assembly |
Estrogen Signaling |
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TH1, TH2, TH9, Th17, and Treg Differentiation |
Differentiation |
FGFR Signaling |
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DNA Damage Repair |
FoxO Signaling |
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Innate Immunity |
EMT |
GPCR Signaling |
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Complement System |
Endocytosis |
Hedgehog Signaling |
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Dendritic Cells |
Epigenetic Modification |
HIF1 Signaling |
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DNA & RNA Sensing |
Immortality & Stemness |
Insulin Signaling |
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Glycan Sensing |
Ion Transport |
JAK-STAT Signaling |
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Host Defense Peptides |
Lysosome |
MAPK Signaling |
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Inflammasomes |
Oxidative Stress |
MET Signaling |
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Myeloid Inflammation |
Phagocytosis |
mTOR Signaling |
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Neutrophil Degranulation |
Proteotoxic Stress |
Myc |
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NK Activity |
RNA Processing |
NO Signaling |
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NLR Signaling |
Senescence |
Notch Signaling |
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RAGE Signaling |
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p53 Signaling |
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TLR Signaling |
Metabolism |
PDGF Signaling |
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Amino Acid Synthesis & Transport |
PI3K-Akt Signaling |
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Immune Response |
Arginine & Glutamine Metabolism |
PPAR Signaling |
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Chemokine Signaling |
Fatty Acid Oxidation & Synthesis |
Purinergic Signaling |
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Cytotoxicity |
Glycolysis & Glucose Transport |
Retinoic Acid Signaling |
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IL-1, IL-2, IL-6 & IL-17 Signaling |
Glycosylation |
TGF-beta Signaling |
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Immune Exhaustion |
IDH1/2 |
VEGF Signaling |
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Interferon Response Genes |
Lipid Metabolism |
Wnt Signaling |
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Lymphocyte Regulation & Trafficking |
Mitochondrial Metabolism / TCA |
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NF-kB Signaling |
Nucleotide Synthesis |
Physiology & Disease |
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Other Interleukin Signaling |
Pentose Phosphate |
Angiotensin System |
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Prostaglandin Inflammation |
Tryptophan & Kynurenine Metabolism |
Circadian Clock |
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TNF Signaling |
Vitamin & Cofactor Metabolism |
Drug Resistance |
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Type I, II, & III Interferon Signaling |
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Glioma |
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Leukemia |
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Matrix Remodeling and Metastasis |
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Melanoma |
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Neuroendocrine Function |
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Prostate Cancer |