Orthotopic Models For Cancer Immunotherapy

Search for new anti-cancer agents therapies and treatment modalities is continuously requiring the development and availability of valuable in vivo tumor models, including, among others, orthotopic models. These, based on an orthotopic tumor implantation as opposed to heterotopic inoculation, permit accurate expression of the biological tumor nature in terms of growth rate, morphology and metastasis, thereby mimicking the disease progress for an accurate assessment of response to anti-cancer therapies.

We are offering the following orthotopic tumor-bearing syngeneic mouse models to perform in vivo efficacy evaluation, which can be built by ex vivo capabilities for biomarkers analysis and immune response characterization.