Strenghten your immuno-oncology research with our complete digital pathology capacities

Explicyte Immuno-Oncology > Latest news > Scientific contents > Strenghten your immuno-oncology research with our complete digital pathology capacities
24
Mar
biomarker testing services immuno-oncology CRO
Date 24 March 2022
Categories Scientific contents

Strenghten your immuno-oncology research with our complete digital pathology capacities

Drawing on our expertise in multiplexed-immunohistofluoresence (IHF) and immunohistochemistry (IHC) assays, we have already developed and validated a series of markers & panels to assess several markers of interest as well as the abundance and spatial distribution of lymphoid and myeloid immune cell subsets. While bringing key answers to address specific questions, our capacities have recently been highlighted in new scientific publications of collaborative works with Institut Bergonié, which we are delighted to share thereafter.

In the era of immuno-oncology (IO) research, there is a tremendous need to i) gain insights into the mechanisms associated with response to immunotherapies, i.e. sensitivity vs resistance, and to ii) identify novel biomarkers that can help select patients likely to benefit from such immunotherapies, either as single agents or in combination with novel drug candidates. Analysis of tumor samples using reliable technologies such as multiplexed immunohistofluorescence (IHF) & immunohistochemistry (IHC) combined to ground-breaking image analysis capacities offers a valuable approach to meet these current challenges.

Drawing on our expertise in IHC and IHF assays, we have already developed and validated a series of markers & panels to assess several markers of interest as well as the abundance and spatial distribution of lymphoid and myeloid immune cell subsets. In addition to implementing validated panels, Explicyte provides tailor-made services to specifically meet the project needs. Furthermore, in order to get an accurate and comprehensive picture from the tumor sample – i.e. considering tumor cells and their microenvironment – all images obtained through slide digitization are processed for analysis using a very well-trained workflow.

 

While bringing key answers to address specific questions, our capacities have recently been highlighted in new scientific publications of collaborative works with the Institut Bergonié, which we are delighted to share thereafter.

 

Publication of Euro J of cancer et al. Regorafenib-avelumab combination in patients with billiary tract cancer (REGOMUNE): a single-arm, open-label, phase II trial

Regorafenib-avelumab combination in patients with biliary tract cancer (REGOMUNE): a single-arm, open-label, phase II trial

Cousin et al., European Journal of Cancer, 2022

 

In this Phase 2 clinical trial, Cousin et al. demonstrated the benefit of the combination between Regorafenib, a multi Tyrosine Kinase inhibitor, and Avelumab, an anti-PDL1 antibody, in cholangiocarcinoma patients. Analysis of baseline tumor samples through multiplexed-IHF combining CD8 (Green) / CD163 (Yellow) / PD1 (Red) / PDL1 (Orange) / IDO1 (Cyan) / CK19 (White) / DAPI (Blue) markers revealed that responder patients were characterized by a higher expression of PDL1 as well as IDO1.   Multiplexed-IHF analysis of tumor sample in phase 2 clinical trial of the combination of Regorafenib and Avelumab

 

Trabectedin plus Durvalumab in Patients with Advanced Pretreated Soft Tissue Sarcoma and Ovarian Carcinoma (TRAMUNE): An Open-Label, Multicenter Phase Ib Study

Toulmonde et al., Clinical Cancer Research, 2021

 Publication Clinical cancer research, Toulmonde et al. Trabectedin plus Durvalumab in Patients with Advanced Pretreated Soft Tissue Sarcoma and Ovarian Carcinoma (TRAMUNE): An Open-Label, Multicenter Phase Ib Study

 

Multiplexed-IHC of ovarian cancer in a clinical study combining Trabectedin ans Durvalumab In this clinical study evaluating the activity of the combination of Trabectidin and Durvalumab, Toulmonde et al. evidenced encouraging clinical benefit in platinium-refractory ovarian cancer patients. Also, multiplexed-IHC combining PDL1 (Brown), CD8 (Green) as well as CD163 (Purple) highlighted association between PDL1 expression and CD8 infiltration level with Progression Free Survival.
74 Comments Author charles_lbs

74 Replies to “Strenghten your immuno-oncology research with our complete digital pathology capacities”

  1. dribeta says: 11 November 2024 at 07:29

    priligy walmart For more information on how we can help please do not hesitate to give us a call at our Hellertown PA office

  2. dribeta says: 22 November 2024 at 01:41

    Various combinations of topical disinfectants astringents or topical antibiotics can be effective when these infections are diagnosed early priligy side effects On the contrary DCI down regulation activity on aromatase could be an interesting therapeutic opportunity in males where T accumulation within certain limits is beneficial

  3. nutritionres says: 27 November 2024 at 12:48

    Thanks for systematic work.nutritionres

  4. ehealthjournals says: 28 November 2024 at 07:22

    Thanks for systematic work.ehealthjournals

  5. peerjournals says: 28 November 2024 at 09:29

    Thanks for systematic work.peerjournals

  6. gastroinsights says: 28 November 2024 at 10:57

    Thanks for systematic work.gastroinsights

  7. pediatricsjournals says: 28 November 2024 at 13:05

    Thanks for systematic work.pediatricsjournals

  8. peerjournals says: 29 November 2024 at 08:02

    Thanks for systematic work.peerjournals

  9. surgeryinsights says: 29 November 2024 at 12:53

    Thanks for systematic work.surgeryinsights

  10. pharmajournals says: 30 November 2024 at 08:42

    Thanks for systematic work.pharmajournals

  11. plugandcharge says: 3 December 2024 at 08:43

    Thanks for systematic work.plugandcharge

  12. potiez says: 3 December 2024 at 10:17

    Thanks for systematic work.potiez

  13. res-botanica says: 3 December 2024 at 17:12

    experience and quality thank you.res-botanica

  14. robertex says: 3 December 2024 at 18:41

    experience and quality thank you.robertex

  15. serristoricountry says: 3 December 2024 at 20:08

    experience and quality thank you.serristoricountry

  16. red-agri says: 4 December 2024 at 07:42

    Thanks for systematic work.red-agri

  17. scholengroep.globalnet says: 4 December 2024 at 09:14

    Thanks for systematic work.scholengroep.globalnet

  18. sourisalavie says: 4 December 2024 at 10:46

    Thanks for systematic work.sourisalavie

  19. studio44 says: 4 December 2024 at 16:35

    experience and quality thank you.studio44

  20. tatsrl says: 4 December 2024 at 18:06

    experience and quality thank you.tatsrl

  21. tecnocostruzionizella says: 4 December 2024 at 19:57

    experience and quality thank you.tecnocostruzionizella

  22. swimanddance says: 6 December 2024 at 08:24

    Thanks for systematic work.swimanddance

  23. thales says: 6 December 2024 at 10:13

    Thanks for systematic work.thales

  24. tournailesbains says: 6 December 2024 at 11:48

    Thanks for systematic work.tournailesbains

  25. traiteur-wn says: 6 December 2024 at 13:24

    Thanks for systematic work.traiteur-wn

  26. unadesinfection says: 7 December 2024 at 07:38

    Thanks for systematic work.unadesinfection

  27. scooterkingalmere says: 7 December 2024 at 11:56

    Thanks for systematic work.scooterkingalmere

  28. tuscanycountryhouse says: 8 December 2024 at 11:16

    experience and quality thank you.tuscanycountryhouse

  29. guardiedicitta says: 8 December 2024 at 16:09

    experience and quality thank you.guardiedicitta

  30. sicop-pentacol says: 9 December 2024 at 09:26

    Thanks for systematic work.sicop-pentacol

  31. bargaouirideau says: 9 December 2024 at 11:50

    Thanks for systematic work.bargaouirideau

  32. concepto says: 9 December 2024 at 13:26

    Thanks for systematic work.concepto

  33. semap says: 11 December 2024 at 08:53

    Thanks for systematic work.semap

  34. errachid says: 11 December 2024 at 10:21

    Thanks for systematic work.errachid

  35. thebestofdayton says: 11 December 2024 at 11:49

    Thanks for systematic work.thebestofdayton

  36. thebestofkansascity says: 11 December 2024 at 13:35

    Thanks for systematic work.thebestofkansascity

  37. thebestofoklahomacity says: 12 December 2024 at 07:17

    Thanks for systematic work.thebestofoklahomacity

  38. thebestoftallahassee says: 12 December 2024 at 08:51

    Thanks for systematic work.thebestoftallahassee

  39. tonerhuset says: 12 December 2024 at 16:46

    experience and quality thank you.tonerhuset

  40. k-kleven says: 12 December 2024 at 18:14

    experience and quality thank you.k-kleven

  41. ashgroveresort says: 13 December 2024 at 09:01

    Thanks for systematic work.ashgroveresort

  42. ashgrovecabins says: 13 December 2024 at 10:38

    Thanks for systematic work.ashgrovecabins

  43. chimneycompanyboston says: 13 December 2024 at 12:07

    Thanks for systematic work.chimneycompanyboston

  44. potensial says: 13 December 2024 at 16:26

    experience and quality thank you.potensial

  45. violiner says: 13 December 2024 at 18:00

    experience and quality thank you.violiner

  46. cabinsbrevardnc says: 16 December 2024 at 08:29

    Thanks for systematic work.cabinsbrevardnc

  47. chimneycompanywestchester says: 16 December 2024 at 10:07

    Thanks for systematic work.chimneycompanywestchester

  48. carolina-cabins says: 16 December 2024 at 11:45

    Thanks for systematic work.carolina-cabins

  49. burtonsupply says: 17 December 2024 at 06:44

    Thanks for systematic work.burtonsupply

  50. colorfullyyours says: 17 December 2024 at 08:10

    Thanks for systematic work.colorfullyyours

  51. consew says: 17 December 2024 at 10:21

    Thanks for systematic work.consew

  52. creativeglazing says: 17 December 2024 at 13:29

    Thanks for systematic work.creativeglazing

  53. bolkan says: 17 December 2024 at 18:18

    experience and quality thank you.bolkan

  54. csgmfoodequip says: 18 December 2024 at 07:12

    Thanks for systematic work.csgmfoodequip

  55. dellafrancadevelopmentgroup says: 18 December 2024 at 10:32

    Thanks for systematic work.dellafrancadevelopmentgroup

  56. djsensationalsounds says: 18 December 2024 at 11:58

    Thanks for systematic work.djsensationalsounds

  57. dormerking says: 18 December 2024 at 13:32

    Thanks for systematic work.dormerking

  58. hattrem-trafikkskole says: 18 December 2024 at 16:31

    experience and quality thank you.hattrem-trafikkskole

  59. violiner says: 18 December 2024 at 17:34

    experience and quality thank you.violiner

  60. dialindustries says: 19 December 2024 at 06:14

    Thanks for systematic work.dialindustries

  61. douglasclear says: 19 December 2024 at 07:48

    Thanks for systematic work.douglasclear

  62. dragonshollow says: 19 December 2024 at 09:20

    Thanks for systematic work.dragonshollow

  63. crcdd says: 19 December 2024 at 10:49

    Thanks for systematic work.crcdd

  64. chimneyserviceboston says: 19 December 2024 at 12:22

    Thanks for systematic work.chimneyserviceboston

  65. eastmainstdental says: 20 December 2024 at 08:27

    Thanks for systematic work.eastmainstdental

  66. dukediagnostic says: 20 December 2024 at 11:27

    Thanks for systematic work.dukediagnostic

  67. drcentralbaking says: 20 December 2024 at 13:08

    Thanks for systematic work.drcentralbaking

  68. baltimahalworcester says: 20 December 2024 at 16:52

    experience and quality thank you.baltimahalworcester

  69. aclotbeach says: 20 December 2024 at 18:31

    experience and quality thank you.aclotbeach

  70. cmorfinance says: 20 December 2024 at 20:06

    experience and quality thank you.cmorfinance

  71. edmersupply says: 21 December 2024 at 07:31

    Thanks for systematic work.edmersupply

  72. davidpokorny says: 21 December 2024 at 09:05

    Thanks for systematic work.davidpokorny

  73. ecustomgutter says: 21 December 2024 at 10:37

    Thanks for systematic work.ecustomgutter

  74. eeclongisland says: 21 December 2024 at 12:29

    Thanks for systematic work.eeclongisland

Leave a Reply

Your email address will not be published.

This field is required.

You may use these <abbr title="HyperText Markup Language">html</abbr> tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <s> <strike> <strong>

This field is required.

Site map Terms Of Service Privacy Policy  © Explicyte - Immusmol 2023 | All Rights Reserved.
WordPress Lightbox