In vivo glioma mouse model recapitulating key human glioblastoma characteristics provides an invaluable resource to assess novel immunotherapy-based strategies aiming at bolstering immune system functions to ultimately improve treatment outcome.
Our validated syngeneic glioma mouse model, based on the intracerebral inoculation of Luc2-expressing GL261 cells which allow tumor growth monitoring by bioluminescence imaging, represents a suitable tool for chemo- and immunotherapy assessment. It shows reproducible and predictable growth characteristics and closely mimics the human disease in terms of tumor progression and anti-tumor response, and recapitulates glioblastoma characteristic features including among others tumor immune cell infiltration, tumor-induced immunosuppression and astrogliosis. Interestingly, the use of immunocompetent syngeneic host makes it well-suited for studying glioma immunology and testing innovative drug candidates for their efficacy in enhancing the anti-tumor response alone or combined with reference therapies.
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The French movie historian Thierry Lefebvre hypothesises that M茅li猫s drew upon each of these works, however in different ways: he appears to have taken the structure of the film-“a visit to the Moon, a Moon landing, an encounter with extraterrestrials with a deformity, an underground trek, an interview with the Man within the Moon, and a brutal return to reality back on Earth”-instantly from the 1901 attraction, but also included many plot parts (including the presence of six astronomers with pseudo-scientific names, telescopes that remodel into stools, a moonshot cannon mounted above floor, a scene by which the Moon appears to approach the viewer, a lunar snowstorm, an earthrise scene, and umbrella-wielding travellers), not to say the parodic tone of the movie, from the Offenbach opera-f茅erie.