Reference: SM0524
Contract type: Full time position, permanent contract
Location: Bordeaux, France
You’re an accredited animal experimentalist with a passion for immune response mechanisms? You have experience with in vivo models for immuno-oncology? You master flow cytometry and other platforms for ex vivo analysis? The perspective of testing innovative cancer immunotherapies creates some excitement?
Keep reading and apply!
About Explicyte
Explicyte is a preclinical and translational contract research organization specialized in immuno-oncology. Our goal is to assist academics, biotechs, and pharmas in the discovery of novel targets and novel cancer immunotherapies.
With a team of 25, we’re a human-sized company, which brings under the same roof cell biologists, immunologists, in vivo scientists, medical oncologists, and bioinformaticians. Focused on sponsors’ projects, our activity also involves in-house R&D and external collaborations, which led to the publication of 25+ papers in high-impact-factor journals.
Based in Bordeaux, our lab is located at the Bergonié Comprehensive Cancer Center, where we work in close contact with medical oncology teams. We believe Explicyte is a place to learn, grow, and have impact in the fight against cancer.
Your position
To strengthen our in vivo preclinical activities, we are looking for an experienced in vivo Immuno-Oncology Study Manager, ready to take up with us the implementation of projects and their protocols, relevant for the testing and development of novel immunotherapeutic modalities.
In your role, you will be responsible for the technical and organizational management of sponsors’ and in-house R&D in vivo studies, from their implementation and performance to data analysis. You will timeously provide deliverables with respect to the project’s requirements and timelines.
You will closely interact with the in vivo team members. You will report to the Study Directors and CSO.
What you will find at Explicyte
Your skills & traits
- •Ph.D – or equivalent – in science and health-related field
- •Accreditation in animal experimentation level 1/2 is mandatory, ethical standards and regulations
- •Deep knowledge and mastery of preclinical tumor-bearing mouse models
- •Expertise in tissue collection and processing for flow cytometry-based analysis
- •Knowledge in the fields of tumor immunology and cancer therapies
- •Minimum 1-2 years’ experience in in vivopreclinical development in a health industry: Pharma, Biotech, CRO…
- •Project management experience (from planning to closing projects)
- •Excellent diligence
- •Strong interpersonal & organizational skills
- •Ability to easily adapt to changing priorities and challenges
- •Enthusiasm, curiosity, and integrity
Your missions & responsibilities
- Provide draft protocols according to the proposed scientific and experimental strategies
- Implement studies – relying on undeniable organizational skills – according to their design and established schedules
- Manage and perform – diligently – in vivo and ex vivo experiments
- Tumor cell line culture and maintenance
- Mastery of anesthesia and surgical gestures
- Tumor cell inoculation (subcutaneous, intradermic, intracranial, mammary fat pad, intrasplenic, etc.)
- In vivo monitoring: tumor growth (physical, bioluminescence), body weight and survival, tolerability evaluation
- Mastery of neuro-oncology related in vivo protocols and models is a plus
- Treatment administration (oral, intraperitoneal, intravenous, intratumoral)
- Sampling of biological tissues (blood, tumor, lymph nodes, organs)
- Ex vivo processing of collected samples for immune or tumor cell isolation, or for further analyses (FACS, ELISA…)
- Capture, analyze and compile data, including quality controls
- Ensure accuracy and completeness of study documentation and timely provide study deliverables
- Write and submit animal referrals for ethical committee approval
- Write internal protocols and standard operating procedures
Apply now!