January 27, 2022 – The CONDOR consortium, led by Pr. Antoine Italiano of the Bergonié Institute (Bordeaux, France) is one of the 17 national awardees in the fifth call for projects in Hospital-University Research in Health (RHU5), selected from the 89 applications submitted. This €30M ($34M) project will benefit from a grant of more than €9.8M ($11.1M) to implement a multi-modal project combining precision medicine and immunotherapies for the management of patients with Soft Tissue Sarcomas (STS).
STS are a group of rare and heterogeneous tumors – representing 1% and 15% of adult and childhood cancers, respectively. Despite well-conducted locoregional treatment, up to 40% of patients develop a metastatic relapse. Standard treatment at the metastatic stage has not evolved since the 1970’s. It is based on the use of chemotherapy protocols whose effectiveness is very limited, with a median survival of less than 18 months. While immunotherapy today represents a therapeutic revolution in the management of many cancers, it is to date not part of the therapeutic arsenal for patients with STS.
The CONDOR project is a consortium combining three expert centers in the management of sarcomas – including project leader Institut Bergonié, Gustave Roussy, the Centre Léon Bérard and Inserm via the Pole de Recherche Clinique and the Centre de Recherche des Cordeliers, as well as three French companies, each recognized for their expertise in their respective fields. These companies are Domain Therapeutics, a worldwide player in the discovery and development of anti-cancer therapies targeting G Protein-Coupled Receptors (GPCRs); Explicyte, experts in tumor and peripheral multiparametric profiling for immuno-oncology biomarker discovery and development, and Owkin, a leader in the field of digital pathology and artificial intelligence. Many of these partners have collaborated together for several years, which increases the ability for the consortium to deliver results within five years of funding.
CONDOR is a unique approach aiming to deliver a therapeutic arsenal based on better knowledge of the STS tumor microenvironment, predictive tools and biomarkers to stratify patients, as well as new immunotherapeutic approaches. The ultimate goal is to double the life expectancy of patients with metastatic STS. More specifically, the consortium will:
- Establish an immunological atlas of sarcomas, thanks to a unique tumor bank comprising more than 20,000 samples with annotated clinical data
- Develop artificial intelligence tools – predictive of response to treatment
- Identify immunological signatures and develop non-invasive biomarker assays
- Develop new immunotherapies targeting GPCRs involved in the immune responses to STS
“This consortium represents tremendous hope for STS patients who are still waiting for effective treatments. I sincerely thank the National Research Agency and the French government for their support for medical innovation and their trust in the CONDOR project,” says Pr. Antoine Italiano of the Institut Bergonié in Bordeaux.
“This project represents a unique opportunity to better understand the impact of the immune system in the pathophysiology of sarcomas; to be able to develop innovative and effective treatment strategies,” says Pr. Wolf-Hervé Fridman of the Centre de Recherche des Cordeliers in Paris.
“We are pleased to be participating in this project, which we believe will help to change the standards of treatment for this type of cancer with such a poor prognosis,” adds Dr. Sophie Postel-Vinay of Gustave Roussy in Villejuif, near Paris.
“The CONDOR RHU will allow us to accelerate knowledge in the field of sarcoma immunotherapy and to propose innovative therapeutic approaches that will change the prognosis for our patients,” says Dr. Armelle Dufresne of the Centre Léon Bérard, in Lyon.
“Given the complexity of treatment resistance mechanisms and precision medicine – through biomarker approaches, this brings a definite advantage, by offering treatments adapted to each patient,” adds Alban Bessede, CEO of Explicyte.
“We are delighted to be able to bring our expertise in artificial intelligence to the CONDOR project. The heterogeneity of STS and the very large amount of data that will be generated by the consortium require the implementation of a machine learning strategy that is essential for the development of precision medicine” explains Charles Maussion, Director of Biomarkers at Owkin.
“Through CONDOR, we will deliver several candidates and aim to rearm the immune system by targeting GPCRs involved in immunosuppressive mechanisms. These new immunotherapies will be an integral part of a personalized medicine strategy, for greater patient benefit,” adds Dr. Xavier Leroy, CSO of Domain Therapeutics.
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Volume then soared to nearly a million by 1936, though Ford was nearer.
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At any given second a number of dozen critical checker players appear to be on line.
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This introduction of an economical and transferable month-to-month ticket induced passenger numbers to rise 12 p.c in 1984 and 23 percent the next year, or 5 million to 33.8 million passengers in 1985.
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Chaudhuri, Saabira. “The 25 Documents You Need Before You Die.” The Wall Street Journal.
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Institutional Historical past, New Jersey State Archives.
Li, Yun (30 January 2020).
Additional to yesterday’s picture of the Alty Underneath-9s with Wayne Rooney, the Manchester Evening News stories that the “The Altrincham Jets had been playing a game on the Soccer Dome close to the Trafford Centre after they spotted the United star alongside his teammate Michael Carrick. Rooney was there to observe son Kai who was playing in another recreation however the Jets had been still eager to impress. Team supervisor Mark Cartwright stated, ‘Rooney was watching his son play in another recreation but he and Michael Carrick posed for a great deal of pictures; they have been pretty good sports’. Stephanie Hewitt, whose eight-year-old son Monty is goalkeeper for the Jets, stated the United fan was ecstatic. She stated, ‘To say the lads have been excited is an understatement and the meeting and picture alternative spurred them on to a 9-2 victory. My youngest brother bought Monty a United equipment the day he was born. I had no say whatsoever in the matter – Monty would be a Purple’. Lots of the group started out at Altrincham FC Saturday morning juniors earlier than forming the below-sevens Jets after which under-nines. They play within the Timperley and District Junior Soccer League and play each Saturday morning, with training on a Friday night”.
In addition, if you are using a security system with software that supports virtualization, you should determine whether the software is configured to allow for remote access.
This technological breakthrough was a significant step forward within the drive to create aircraft small sufficient to make use of local airports but subtle sufficient to fulfill the required pace, range, consolation and security requirements of a commercial aircraft.
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All these phrases are related to sleep: an “oreiller” is a pillow, a “lit” is a mattress and “nuit” is night.
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It additionally has unique entry to the woods, along with neighbouring properties.
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In 2005, the National Association of Securities Dealers fined Raymond James $2.75 million for lax supervision of producing branch managers.
That year, President Abraham Lincoln declared two national days of Thanksgiving: one Aug.
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As soon as you are safely off the road, put the automobile in park, have interaction the emergency flashers, and get everyone out of the car and right into a secure spot before calling for help.
A: It is indeed true that 80 of the so-known as cash managers (truly mutual fund managers are the universe utilized in such research) underneath carry out the typical (i.e., the market indexes).
Reuters. Ostroukh, Andrey; Tétrault-Farber, Gabrielle; Vaal, Tamara (10 March 2020).
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Despite dismissal, Valdés returned to the touchline in Might 2020, when he was appointed the supervisor of UA Horta.
Lawler, Ryan (16 May 2017).
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McFadden is the author of the James Beard Award-winning book “Six Seasons: A brand new Manner With Vegetables,” which he wrote with Martha Holmberg.
The Shweeb rails are powered to enable sensor and security programs, but the pods themselves move beneath human energy.
In the 1940s to the early 1960s, Armitage was the chief stained glass designer for James Powell and Sons.
Sacred Coronary heart Church, Wilbur.
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There are a number of ways to generate ideas and you can test the waters by having your own in-house event.
There appears to be little optimism that this yr will see a lot constructive motion to cut back the carbon emissions that contribute to global warming and climate change, as enshrined in the Kyoto Protocol, the local weather change treaty.
Star Wars issues. Strolling instructions from station: Take the north exit, go straight (on any of the three streets leading north) until the road deadends, flip left and when that avenue deadends, will probably be right in entrance of you — see the brand and familiar faces on the second flooring.
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Her image was later included in the coaching simulations on the Jedi Temple on Coruscant.
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Washington became ailing with tuberculosis.
This carat weight varies according to the astrological horoscope of the wearer.
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The 2008 presidential campaign of Bob Barr, former Congressman of Georgia began on Could 12, 2008.
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June 20, 1923. p.
The National Institute of Mental Well being (NIMH) lays out the symptoms which can be widespread to a manic episode.
Stephen Entwistle, Navy Methods Office, Vickers Shipbuilding and Engineering Ltd, Barrow-in-Furness.
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This is taken into account the strongest response, since Black can usually take and keep the pawn on c4.
The Royal Scottish National Hospital was a psychiatric establishment situated in Larbert, Falkirk, Scotland.
This type of funding allows you to sell your future receivables at discounted prices so that you can use funding for small business loans, cash advance, working capital, receivables financing, restaurant equipment, retail funding, business loan, financial service, Unsecured loans, MasterCard sales, Credit Card Receivables, equipment purchases, advertising, renovations, expansion and more.
Bongiorno, Lori. ”What’s losing vitality in your house proper now?
Forbearance intervals vary in length, lasting wherever from a number of months to a few years.
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The season was a mixed bag for Barthez.
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For merchandise used in automotive, 727 recalls have been linked to hearth hazards with 78 recalls related to electrical fires and 43 associated to battery fires.
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In February 2023, York Capital Administration portfolio company American Car Heart ended operations.
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He was an elder at First Presbyterian Church in Palestine and the Ralston Memorial Presbyterian Church in Houston.
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After three unsuccessful makes an attempt at gaining an advantage with 1.e4, Karjakin performed 1.d4 for the first time in the match.
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This rate would allow income to be fully adjusted for inflation every year thereafter and still maintain a positive balance at the end of every 30-year period.
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The Masked Dancer” 2022: Das ist das neue Rateteam”.
When you’ve got a private story about butting heads with your insurance coverage firm to get a surgery or coverage for a prescription drug , you most likely understand why the United States pursued well being care reform.
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How can learning new skills boost mental wellbeing?
Sidious makes use of as a puppet to control the primary Order and seduce Kylo Ren to the darkish side.