Reference: SM1025
Contract type: Full-time position, permanent or fixed-term contract
Location: Bordeaux, France
Are you an experienced research associate passionate about immuno-oncology? Do you have proven expertise in immune cell isolation, culture/co-culture, and multiparametric flow cytometry? Have you contributed to innovative research programs in cancer immunotherapy, driving the setup, execution, and analysis of in vitro/ex vivo experimentations? If so, we want to hear from you!
About Explicyte
Explicyte is a preclinical and translational contract research organization specialized in oncology & immunology. Our goal is to assist academics, biotechs and pharmas in the discovery of novel targets and for the development of novel cancer immunotherapies.
With a team of 25 scientists, we’re a human-sized company, which brings under the same roof cell biologists, immunologists, in vivo scientists, medical oncologists and bioinformaticians. Focused on sponsors’ projects, our activity also involves in-house R&D and external collaborations, which led to the publication of 30+ papers in high-impact-factor journals over the last 5 years.
Based in Bordeaux, our lab is located at the Bergonié Comprehensive Cancer Center, where we work in close contact with medical oncology teams. We believe Explicyte is a place to learn, grow, and have impact in the fight against cancer.
Your position
Within our in vitro team, you will primarily support a major sponsored R&D program, while contributing to other internal initiatives. You will be responsible for executing in vitro / ex-vivo experiments with autonomy and rigor, ensuring timely capture, analysis, and reporting of data.
You will interact closely with all team members, including study directors, and will report directly to the CSO.
What you will find at Explicyte
Your skills & traits
- Ph.D. or Master’s degree in cell biology, immuno-oncology, biotechnology, pharmacology, or related fields
- Minimum 3/4-year experience in biotechnology, pharma, CRO, or academic research, ideally in oncology/immuno-oncology
- Solid knowledge of tumor immunology and cancer therapies
- Expertise in immune cell isolation, culture / co-culture, and immune phenotyping
- Expertise in multiparametric flow cytometry and functional immune cell-based assays
- Skilled in data acquisition, analysis, and visualization tools (FlowJo, Incucyte, GraphPad Prism)
- Strong record in project management, with proven ability to plan, execute, and document experiments autonomously and meticulously
- Excellent organizational, interpersonal, and communication skills
- Experience with 3D cultures (spheroids, organoids) is a plus
- Proficient in written scientific English (reading protocols, writing reports)
Your missions & responsibilities
- Implement and manage studies autonomously, ensuring rigorous and timely execution according to schedules
- Draft protocols based on proposed scientific and experimental strategies.
- Design & execute experimental workflows, including plate setup, treatment conditions, and dose-response functions
- Perform functional in vitro immuno-oncology assays, including pharmacological and gene-editing approaches
- Isolate, culture/co-culture, and characterize immune cells for functional immuno-oncology assays
- Maintain, characterize, and validate tumor cell lines
- Collect and process samples, including cells and supernatants, for downstream analyses
- Prepare samples for omics analyses, including RNA-seq and proteomics.
- Design and perform multiparametric flow cytometry panels for immune phenotyping, cytotoxicity, and T cell activation analyses
- Capture, analyze, and compile cytokine responses (LEGENDplex, flow cytometry)
- Capture and analyze live-cell imaging kinetics and compile experimental data
- Ensure high-quality data capture, accuracy, and completeness of study documentation
- Deliver analyzed data in accordance with study requirements
- Contribute to experimental development by implementing methodological improvements
Apply now!