A new cost-saving in vivo shuttle session on syngeneic tumor mouse models
09 / 01 / 2021
MC38 colon, LLC1 lung, Renca renal, EMT-6 breast, MCA205 sarcoma and CT26 colon tumor-bearing mouse models exhibit various tumor growth profiles and differential responsiveness to PD1 or CTLA4 blockers. Mice were challenged with respective tumor cells and exposed to vehicle or anti-PD1 or anti-CTLA4 antibodies. Tumor growth was then monitored overtime. Upper panel: The three tumor models are differentially sensitive to PD1 blockade – MC38 model being responsive while LLC1 and Renca tumors are resistant. Lower panel: The three tumor models - EMT6, MCA205, and CT26 - are differentially and partially sensitive to CTLA4 blockade.
Registration form - In vivo shuttle session
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