In vitro assessment of functional response to PD1 blockade

06 / 27 / 2019

Relying on our validated in vitro immune cell activation assay based on the HTRF quantitation of key cytokine release, we recently documented functional characterization of PD1 blockade.

Indeed, the data presented in our white paper allowed for highlighting the accuracy and reliability of combined in vitro approach based on live cell imaging and human IFNg released level quantification as surrogate predictive index for the robust assessment of functional responses to anti-PD1 antibodies.
This global approach thus constitutes a powerful tool to evaluate, in general, candidate biologics for their immunomodulatory properties of immune cell activation, thereby empowering Immuno-Oncology drug discovery programs.

To learn more, download our white paper !