Conversing with Professor Antoine Italiano, a worldwide expert on early drug development, phase I oncology trials and immuno-oncology, upon the release of a recent article in Clinical Cancer Research.
Professor Italiano delves into the major insights from this groundbreaking publication and offers his perspective on the upcoming trajectory of cancer immunotherapy.
Read the paper here, titled “Upregulation of Indoleamine 2,3-dioxygenase 1 in tumor cells and tertiary lymphoid structures is a hallmark of inflamed non-small cell lung cancer”.
Pr. Italiano: The key to identifying biomarkers for immunotherapy lies in patient samples. I am very indebted to the generosity of the patients who consented to participate in the Bergonié Institute Profiling program.
What are the current challenges of immunotherapy for lung cancer management?
Pr. Italiano: Lung cancer ranks as the top cause of cancer-related deaths in Western countries. Until recently, its primary treatment was chemotherapy, which had limited efficacy with response rates under 20%.
Subsequent advances introduced immunotherapy, specifically using monoclonal antibodies that target the programmed cell death-1 (PD-1) or its ligand (PD-L1). However, this approach has been effective in fewer than 30% of patients.
The primary challenge now lies in expanding the percentage of lung cancer patients who can benefit from immunotherapy. This requires a deeper understanding of resistance mechanisms and the development of strategies to overcome them.
Why are tertiary lymphoid structures the backdrop of this research?
Pr. Italiano: For several years, my team has been investigating the role of B cells in a cancer’s response to immunotherapy. These cells are primary components of tertiary lymphoid structures (TLS) found in inflamed tissues.
Our research has demonstrated that the presence of TLS enhances the likelihood of a positive response to immune checkpoint inhibitors across various cancer types. However, this finding is not universally applicable, as not all patients with TLS-positive tumors exhibit a response to the treatment.
What key results did you prove?
Pr. Italiano: This research seeks to elucidate why certain lung cancer patients with TLS exhibit resistance to immunotherapy (PD-1/PD-L1).
To achieve this, we delved into specific facets of tumor metabolism, emphasizing the kynurenine pathway’s immunosuppressive function. Our primary focus was the indoleamine 2,3-dioxygenase (IDO) enzyme, pivotal in the conversion of tryptophan to kynurenine. Our findings indicate a strong correlation between IDO activity and a favorable treatment response in these patients.
Notably, and this underscores the novelty of our study, we propose that IDO acts to modulate TLS activity in these scenarios.
What are the clinical implications of these findings?
Pr. Italiano: A direct implication of our findings suggests the combination of commonly utilized checkpoint inhibitors with an IDO inhibitor, specifically targeting the identified subgroup of lung cancer patients with an inflamed tumor microenvironment. This approach signifies a significant stride towards precision medicine in cancer immunotherapy.
Furthermore, with the right patient selection, IDO inhibitors could see a resurgence in interest, underscoring the potential of this therapeutic strategy.
To finish, what immunotherapy will be like in the future?
Pr. Italiano: The future of immunotherapy strategies hinges on precise patient selection to enhance efficacy.
Given that knowledge in immuno-oncology is doubling approximately every two years, integrative approaches that consolidate diverse research findings will undoubtedly enrich cancer immunotherapy.
For each patient, we should have access to an optimal combination of treatments guided by a specific array of biomarkers. I am confident that this will be realized through the power of artificial intelligence!
ePDhnqfoTHaI
QxXlstUveGF
QvoUraPDumBpRzYh
I like the comprehensive information you provide in your blog. The topic is kinda complex but I’d have to say you nailed it! Look into my page UQ5 for content about Airport Transfer.
priligy cost During LASIK Surgery
In the ED patients with signs and symptoms of pneumonia had a blood sample collected for routine biochemical and haematological determinations and PCT concentration measurement priligy kaufen Tyrosine hydroxylase expressing C1 neurons of the rostral ventrolateral medulla respond to hypoxic conditions and activate the locus coeruleus Abbott et al
thank you nice job.nursingres
According to this model K Ras activation of type II cells leads to adenocarcinoma because these cells are able to sustain or maintain Notch signaling when K Ras is activated cytotec generic All the conditions that are associated with Bone spur
thank you nice job.clinicalmedicaljournal
thank you nice job.nursingres
thank you nice job.escientificjournals
thank you nice job.escientificjournals
thank you nice job.healthcareinsights
thank you nice job.clinicalmedicaljournal
thank you nice job.peerreviewedjournal
thank you nice job.esciencejournal
thank you nice job.enursingcare
Although there is no direct evidence if lung microbiome can affect potential SARS CoV 2 infections and the outcomes of this disease yet several lines of evidence support that bacteria in lungs have important roles in this disease comprar cytotec online Doctors advise against taking amoxicillin and alcohol together because this can lead to
thank you nice job.maisonmedicaledelaeken
experience and quality thank you.leragazzedifirenze
experience and quality thank you.loconteedilecostruzioni
experience and quality thank you.monicavignoliniluxury
thank you nice job.mayablog
thank you nice job.menuiserie-delbart
thank you nice job.menuiseriemorlighem
experience and quality thank you.prato-pronto-effetto
thank you nice job.mysantaria
experience and quality thank you.prontointervento-multiservice
experience and quality thank you.francobianchi
thank you nice job.probat-tunisie
thank you nice job.probat-tunisie
thank you nice job.cliniquemtarhemodialyse
thank you nice job.biocontrol
thank you nice job.safi-ingenierie
thank you nice job.thebestofeugene
thank you nice job.thebestoflasvegas
thank you nice job.thebestofwichita
experience and quality thank you.resan
experience and quality thank you.roger-jensen
experience and quality thank you.sk-veilag
thank you nice job.bellmoreglass
thank you nice job.bellmoreglassandmirror
experience and quality thank you.stubbanvel
thank you nice job.bbdps
thank you nice job.268dental
thank you nice job.brotherspastries
thank you nice job.brooklynterminalmarketonline
Rely on BWER Company for superior weighbridge solutions in Iraq, offering advanced designs, unmatched precision, and tailored services for diverse industrial applications.
thank you nice job.bspo-ken
thank you nice job.americanpridefasteners
thank you nice job.americanmufflerautorepair
thank you nice job.apsbox
experience and quality thank you.tela
experience and quality thank you.sj-transport
experience and quality thank you.tkbl
thank you nice job.arditomason
thank you nice job.arbemachine
thank you nice job.aquavaria
thank you nice job.ash-grove
thank you nice job.atlasrolloff
experience and quality thank you.storen-servicesenter
thank you nice job.autoproautomotiveservice
thank you nice job.bakerpersonnel
thank you nice job.barbatonursery
thank you nice job.balcosupply
thank you nice job.bayshorepaper
thank you nice job.bsyd
experience and quality thank you.fcdf-ye
experience and quality thank you.bwnivelles
experience and quality thank you.dkstechnoholdings
thank you nice job.catchasilverstar
thank you nice job.casaconcreteinc
thank you nice job.cavalierifuel
thank you nice job.centralwindowcleaning