We rely on consulting pathologists to develop a robust experimental strategy, including:
- Sample qualification
- Slide annotation
- Marker validation
- Scoring of standard biomarkers (Ki67, PDL1, HER2, …)
- TLS scoring
Marie Brevet, MD, PhD
- Pathologist at Technipath, Synlab.
- CEO of Biwako, French company dedicated to medical research.
- Areas of expertise: Biomarkers in oncology, AI, molecular pathology, biobank, clinical research.
Lucile Vanhersecke, MD
- Pathologist at the Institut Bergonié Cancer Center.
- Expert for the French national sarcoma review network.
- Areas of expertise: AI, solid tumors, predictive markers of immmune response, immunotherapy, Tertiary Lymphoid Structures.
Transcriptomics for target discovery
- Single-cell transcriptomics using probe-based (Flex), 3’ or 5’ gene expression (Chromium platform)
- Spatial transcriptomics based on GeoMx digital spatial profiling or single-cell Xenium platforms
Digital pathology for validation
- Custom IHC/IHF panels based on 150+ validated markers
- Automated staining and slide digitization: up to 100 samples stained per week, high-throughput scanning
In-house image & data science
- Image analysis: AI-based tissue & cell segmentation, gene expression mapping
- In-depth statistical analysis: gene expression analysis, signature analysis, generation of heatmaps, volcano plots
Experts
in Immuno-Oncology
- A comprehensive & automated platform including digital pathology, singe-cell and spatial transcriptomics, proteomics, flow cytometry, and more.
- Over 10 years of experience in TME & peripheral marker profiling
- 30+ translational studies published in key immuno-oncology journals
Personalized
approach
- Scientific interactions to align target identification & validation strategies with appropriate samples & analytical technologies
- A dedicated study director (PhD) overseeing your project from experimental plan to final report discussion
- Tailored bioinformatics analysis to make the most of your dataset
Your contacts
Talk to our team !
Paul Marteau, PharmD (preclinical study director), Imane Nafia, PhD (CSO), Loïc Cerf, MSc (COO), Alban Bessede, PhD (founder, CEO), Jean-Philippe Guégan, PhD (CTO)
Tell us about your project !
Tumor FFPE Tissue Samples: Custom Sourcing & Analysis I CRO Services in Immuno-Oncology
Explicyte Immuno-Oncology provides CRO services for the custom sourcing of FFPE tumor tissue samples, and their subsequent analysis to support the identification and validation of novel therapeutic target and biomarkers. To provide our translational services, we rely on a partnership with an accredited tumor tissue bank, consulting pathologists, and a comprehensive technology plartform including digital pathology, single-cell RNASeq and single-cell spatial transcriptomics. Our in-house data science team is in charge of image analysis, statistics, and graph generation. So far, our translational team served industrial and academic sponsors in Europe, including France, Germany, France, Italy, UK, Denmark, Sweden, and Switzerland), and USA, Canada, Japan, Korea.