Digital pathology
- In-house tissue processing capacities fixation, paraffin embedding, slicing, annotation by trained pathologist
- Over 100 validated markers for custom multiplex panel
- Automated staining (IHC/IHF): 2x automated Ventana Discovery systems
- Multiplex Pathology Imaging: Multispectral imaging with PhenoImagerTM (Akoya Biosciences, 2 systems)
- Pathologist-assisted image analysis and in-house data science team for custom image segmentation
Spatial transcriptomics platforms
- GeoMx by Nanostring: Designed for discovery studies, this platform offers digital spatial profiling in specific regions of interest using a comprehensive probe panel, such as the Whole Transcriptome Atlas, which covers 18,000 protein-coding genes.
- Xenium by 10x Genomics: Ideal for validation and characterization studies, Xenium provides single-cell spatial transcriptomics, enabling detailed analysis of gene expression profiles for each cell within the sample, with a probe set of up to 5,000 genes.
In-house image analysis & data science team
- AI-based capacities in image analysis for tissue & cell segmentation, and gene expression mapping
- Data representation: production of heatmaps and volcano plots
- In-depth statistical analysis: exploration of signaling pathways, signatures, spatial heterogeneity
Experts
in Immuno-Oncology
- 30+ papers released over the past 5 years in the field of immuno-oncology with a focus on translational studies
- 10-year experience >10,000 samples processed to explore the mechanisms associated with sensitivity to cancer therapies
- Peripheral biomarkers a comprehensive platform encompassing cytokine profiling, single-cell RNASeq, proteomics, and flow cytometry
Personalized
approach
- Custom experimental design sampling and panel strategy adjusted to your needs and samples
- A dedicated study director (PhD) to tailor the experimental plan to your need and discuss results
- In-house data science team to make the most of your spatial biology dataset
Your contacts
Talk to our team !
Paul Marteau, PharmD (preclinical study director), Imane Nafia, PhD (CSO), Loïc Cerf, MSc (COO), Alban Bessede, PhD (founder, CEO), Jean-Philippe Guégan, PhD (CTO)
Tell us about your project !
Spatial biology CRO services for immuno-oncology I Spatial Biomarker Analysis I Cancer Immunotherapy
Explicyte Immuno-Oncology offers spatial biology CRO services to drive the discovery of novel cancer immunotherapy targets, analyze spatial biomarkers within the tumor microenvironment, and evaluate new compounds in the field of precision oncology. Our histology services are supported by expert histopathologists and a state-of-the-art digital pathology platform. Additionally, our spatial omics capabilities include single-cell spatial transcriptomics and digital spatial profiling, enabling comprehensive analysis of tumor specimens.