20+ colleagues
Explicyte is a human-sized company that brings cell biologists, immunologists, medical oncologists and data scientists under the same roof.
High-tech platform
Spatial transcriptomics, advanced proteomics, digital pathology … Each year we invest ~15% of our turnover in research and instrumentation. Tech enthusiasts welcome!
Science with impact
Located in the Bergonié Comprehensive Cancer Center, we work in close relationship with clinicians and drug developers to advance novel immunotherapy strategies.
Contract type: Full time position, permanent contract
Location: Bordeaux, France
You are passionate about the interplay between immune and tumor cells? You have experience with 3D tumor-based culture models in the perspective of testing innovative cancer immunotherapies? You are proficient in flow cytometry and multiparametric platforms for in vitro/ex-vivo analyses? Keep reading and apply!
The position
We are looking for an experienced in vitro Immuno-Oncology Scientist, ready to take up with us the setup and operation of 3D tumor model cultures, relevant for the testing and development of novel immunotherapeutic strategies.
In your role, you will be the scientific-technical referent in 3D cell culture, on all of R&D projects and Sponsors’ studies. You will interact with the in vitro team members.
You will have versatile & empowering missions. You will report to the Chief Scientific Officer.
What you will find at Explicyte
Your skills & traits
- Post-graduate degree (MSc/PhD) in oncology, immuno-oncology, or related fields
- Expertise in 3D cell culture models and protocols (i.e. organoids, fragments, spheroids), with a minimum 3 years of experience
- Expertise in multiparametric analysis methodologies, e.g. flow cytometry, kinetic high content imaging, multiparametric supernatant analyses (LEGENDplex, Olink, etc), immunohistofluoresence
- Expertise in 2D cell culture protocols (immune/tumor cell co-cultures, immune cell isolation and cultivation, differentiation and polarization protocols)
- Proficiency in project management: from implementation and performance to data analysis and on time rendering of deliverables. Ability to manage multiple projects simultaneously
- Strong interpersonal & organizational skills
- Ability to easily adapt to changing priorities and challenges
- Fluency in written and oral English
Your missions & responsibilities
- Define, implement, and adapt adequate protocols according to the scientific purpose
- Provide draft protocols according to the scientific and experimental strategies
- Implement studies - relying on undeniable organizational skills - according to their design and established schedules
- Be responsible for handling and processing fresh tumor samples upon their receipt for their usability in 3D cultures
- Manage and perform - diligently - in vitro and ex-vivo experiments
- Cell culture-based experiments for functional immuno-oncology assays
- 3D tumor model cultures: organoids, tumor fragments, and spheroids, etc
- Ex vivo processing of collected samples for immune or tumor cell isolation, or for further analyses (FACS, ELISA…)
- Capture, analyze and compile data, including quality controls
- Ensure accuracy and completeness of study documentation and provide study deliverables on time
- Write internal protocols and standard operating procedures
- Contribute to experimental development by implementing new methods and training other collaborators and team’s members
About us
Explicyte is a preclinical and translational contract research organization specialized in immuno-oncology. Our goal is to assist academics, biotechs, and pharmas in the discovery of novel targets and novel cancer immunotherapies.
With a team of 25, we’re a human-sized company, which brings under the same roof cell biologists, immunologists, in vivo scientists, medical oncologists, and bioinformaticians. Focused on sponsors’ projects, our activity also involves in-house R&D and external collaborations, which led to the publication of 30+ papers in high-impact-factor journals.
Based in Bordeaux, our lab is located at the Bergonié Comprehensive Cancer Center, where we work in close contact with medical oncology teams. We believe Explicyte is a place to learn, grow, and have impact in the fight against cancer.
More about us
Apply now!
Contract type: Full-time position, permanent contract
Location: Bordeaux, France
You like to play with large multi-omics datasets and analyze spatial information ? You have an interest in the biological processes involved in the response to cancer immunotherapies ? Keep reading and apply!
About Explicyte
Explicyte is a preclinical and translational contract research organization specialized in immuno-oncology. Our mission is to support academics, biotechs and pharmas in the discovery of novel targets and novel cancer immunotherapies.
With a team of 25, we’re a human-sized company, which brings under the same roof cell biologists, immunologists, medical oncologists and bioinformaticians. Focused on sponsors’ projects, our activity also involves in-house R&D and external collaborations, which led to the publication of 30+ papers in high impact-factor journals.
Based in Bordeaux, our lab is located at the Bergonié Comprehensive Cancer Center, where we work in close contact with medical oncology teams. We believe Explicyte is a place to learn, grow, and have impact in the fight against cancer.
More about us
Your position
To strengthen our translational research activities and benefit our partners, we are currently looking for a trained Data Scientist with expertise in single-cell analysis.
In your role, you will be accountable for data mining & analysis in relation to sponsors’ and R&D studies. You will play with data from various biological samples (e.g. FFPE & fresh tumor samples, Peripheral Blood Mononuclear Cells, tumor immune infiltrates, etc.), captured through a range of platforms that include Chromium (10X Genomics) for single cell analysis, Geomx DSP (Nanostring) for spatial transcriptomics as well as Xenium (10X genomics) for in situ single cell analysis.
You will interact with the translational team, and will report to the Chief Technology Officer.
What you will find at Explicyte
Your skills & traits
- Post-graduate degree (MSc/PhD) in computational biology, in bioinformatics, or biostatistics
- Proficiency in R programming language (markdown, shiny…) is mandatory. Other languages (Python, Groovy, mySQL…) are a plus
- Experience with scRNA sequencing data analysis and other single-cell technologies.
- Knowledge of basic and multivariate statistics is required
- Monitoring scientific papers to stay up-to-date with latest advancements for analysis
- Strong analytical and problem-solving abilities.
- Excellent communication and teamwork skills.
- Previous experience in a clinical research or bioinformatics environment is required.
Your missions & responsibilities
- Grasp the underlying biological issues and research questions to guide data analysis strategies effectively
- Collaborate closely with the Data Science Director, Study Managers, and interdisciplinary teams to optimally define and refine analysis criteria that align with project objectives
- Collect, process, analyze, and compare large-scale datasets originating from diverse sources, including bulk and spatial single-cell genomics
- Utilize existing bioinformatics tools and develop novel solutions as necessary to facilitate comprehensive data mining and analysis, encompassing large-scale data integration, supervised and unsupervised learning, statistical modeling, genomic analysis, and deep learning techniques
- Generate and run data analysis reports that support research teams in delivering study outcomes that meet project requirements and adhere to established deadlines
- Contribute to scientific publications as necessary
Apply now!
2012-2014
ImmuSmol’s in vivo services
In 2012, freshly out of post-doc, immunologist Alban Bessede launched ImmuSmol, a biotech company developing antibodies against kynurenine pathway metabolites for diagnostic & therapeutic use. Building on Alban’s expertise in syngeneic tumor models treated with immune checkpoint inhibitors, ImmuSmol started to provide in vivo services on the side, to finance in-house R&D projects.
2015-2019
Launch of Explicyte Immuno-Oncology
In 2015, ImmuSmol launched a dedicated brand for ImmuSmol’s contract research activity in immuno-oncology: Explicyte. Adding capacities in in vitro screening and immune profiling (flow cytometry, digital pathology), Explicyte expanded its services to become a full-blown preclinical CRO. At the time, we company was located at the Biomedical Innovation Platform of the University of Bordeaux.
2020-2024
Pivot toward translational research
In 2020, the company moved to the Bergonié Comprehensive Cancer Center. Close collaboration with medical oncologists led the company to develop translational research projects and build a precision medicine platform. Scientific collaborations resulted in high-impact publications and team reinforcement with PhDs & MDs.
We are the proud sponsors of the “Rugby Touch” team of the Institut Bergonié
Apply now !
Close to the city center of Bordeaux
We’re located at the Bergonié Institute (10 minute walk from the city center). You can go to work by train, tram or cycling. We take in charge 50% of your public transportation expenses.
A house with a garden !
In 2024, we moved to a freshly renovated house next to the Institut Bergonié. It’s a place for office work, meetings, lunchtime, and social events.
Young parents welcome
We arrange day-nursery for babies. And we are flexible in terms of working schedules, to make the life of young parents at little bit less challenging.
