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The data shown here illustrate our DC differentiation and mixed leukocyte reaction (MLR) assay as a valuable and robust tool to address DC function and evaluate the modulation of their mediated immune response. Based on a co-culture of allogenic CD4 T cell (responder) and monocyte-derived DCs (stimulator), our assay is specifically configured to get either basal MLR (Fig 1) or impaired response (Fig 2) due to an immunosuppressive condition, e.g. Adenosine, leading to tolerogenic and functionally dysregulated DCs. This thus makes it well suited for evaluating biologics for their modulating ability to either i) amplify an immune response or ii) alleviate an immunosuppressive condition and trigger DC-mediated T cell-stimulating activity.
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