3 service offers based on the Visium CytAssist

Visium cytassist whole transcriptome services CRO

Visium Whole-Transcriptome Panel

  • Eligible samples: FFPE & frozen tissues (mouse & human)
  • Panel: ~18K protein-coding genes, with optional immuno-oncology protein add-on
  • Resolution: 55µm barcoded spots
  • Capture area: Up to 11 mm x 11 mm

Advantage: FFPE-compatible, cost-efficient, large field of capture

Visium HD Whole transcriptome services CRO spatial transcriptomics

Visium HD Whole-Transcriptome Panel

  • Eligible samples: FFPE & frozen tissues (mouse & human)
  • Panel: ~18K protein-coding genes
  • Resolution: 2μm barcoded squares
  • Capture area: 6.5 x 6.5 mm (2 capture areas per slide)

Advantage: FFPE-compatible, enhanced sensitivity & resolution

Visium HD 3' Gene Expression services CRO

Visium HD 3’ Gene Expression

  • Eligible samples: Fresh-frozen tissues (any species)
  • Panel: 3’poly(A) whole-transcriptome capture
  • Resolution: 2μm barcoded squares
  • Capture area: 6.5 x 6.5 mm (2 capture areas per slide)

Advantage: Multi-species, ideal for de novo discovery (isoform, TCR/BCR, SNV detection)

Our capabilities to support Visium-based spatial biology studies

Single-cell spatial biology transcriptomics tumor biopsies FFPE services CRO oncology

Sample sourcing & in-house processing

  • Custom sourcing access to human tumor specimens via accredited French biobanks
  • Rigorous sample QC: RNA integrity assessed by RNAscope/DV20
Visium HD Services CRO 10x genomics spatial gene expression profilingVisiumHD Cytassist 10x CRO services spatial transcriptomics

Standard data package

  • Raw data processed with 10x Space Ranger: alignment, spatial barcode deconvolution, gene-expression quantification per spot
  • Matching of gene expression map with high-resolution image
  • Web summary report, including key metrics, clustering, top features by cluster
Visium HD custom data analysis services CRO data science

Custom data science

  • Customized analysis based on proprietary workflows & algorithms
  • Custom nuclei and cell segmentation to assign transcripts to inferred cells
  • Manual cluster annotation to reveal tissue architecture
  • Custom pipeline and graphs: integration of multiple samples, differential expression, pathways and cell-cell communication analyses

Why working with Explicyte?

Experts
in Immuno-Oncology

  • Proven Expertise: +30 peer-reviewed publications in the field of immuno-oncology in the last 5 years
  • 10-year experience: Over 10,000 samples processed to explore mechanisms associated with sensitivity to cancer therapies.
  • Comprehensive Data Integration: Enhance your dataset with additional information from H&E staining and mIHF/IHC assays.

Personalized
approach

  • Tailored experimental design – sample and panel selection – to align with your unique requirements and specific sample types.
  • Dedicated Expertise: Benefit from a dedicated PhD study director who will tailor your experimental plan and offer thorough discussions of your outcomes.
  • Comprehensive Bioinformatics Support: Utilize our in-house bioinformatics pipeline crafted to maximize the value of your spatial dataset.

Your contacts

explicyte team 2024

Talk to our team !

Paul Marteau, PharmD (preclinical study director), Imane Nafia, PhD (CSO), Loïc Cerf, MSc (COO), Alban Bessede, PhD (founder, CEO), Jean-Philippe Guégan, PhD (CTO)

Tell us about your project !

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    Visium HD services for Whole-Transcriptome Spatial Biology

    Explicyte provides spatial transcriptomics services based on the Visium Cytassist HD platform by 10x Genomics. Complementing our single-cell platforms (Xenium, Chromium), the Visium HD creates opportunities for faster and cost-effective spatial transcriptomics data. Our team can source human specimens to meet your need, and provide custom data science services to make the most of your dataset.

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