Publications & Articles

Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohort

05 / 26 / 2022

Pembrolizumab in soft-tissue sarcomas  with tertiary lymphoid structures: a phase 2  PEMBROSARC trial cohort

Nature medicine, 2022, May 26
A. Italiano , A. Bessede, M. Pulido, E. Bompas , S. Piperno-Neumann, C. Chevreau, N. Penel, F. Bertucci, M. Toulmonde, C. Bellera, J. P. Guegan, C. Rey, C. Sautès-Fridman , A. Bougoüin, C. Cantarel, M. Kind, M. Spalato, B. Dadone-Montaudie, F. Le Loarer, J. Y. Blay  and W. H. Fridman

Spatial transcriptomics of macrophage infiltration in non-small cell lung cancer

02 / 22 / 2022

Spatial transcriptomics of macrophage infiltration in non-small cell lung cancer

Spatial transcriptomics of macrophage infiltration in non-small cell lung cancer reveals determinants of sensitivity and resistance to anti-PD1/PD-L1 antibodies

Journal for ImmunoTherapy of Cancer, 2022, Feb 22
Mathieu Larroquette, Jean-Philippe Guegan, Benjamin Besse, Sophie Cousin, Maxime Brunet, Sylvestre Le Moulec, François Le Loarer, Christophe Rey, Jean-Charles Soria, Fabrice Barlesi, Alban Bessede, Jean-Yves Scoazec, Isabelle Soubeyran, Antoine Italiano

Regorafenib-avelumab combination in patients with biliary tract cancer (REGOMUNE)

01 / 05 / 2022

Regorafenib-avelumab combination in patients with biliary tract cancer (REGOMUNE)

Clinical Trial, 2022, Jan 5
Sophie Cousin
, Coralie Cantarel, Jean-Philippe Guegan, Thibault Mazard, Carlos Gomez-Roca, Jean-Philippe Metges, Carine Bellera, Antoine Adenis, Iphigenie Korakis, Pierre-Guillaume Poureau , Kevin Bourcier, Maud Toulmonde, Michèle Kind, Christophe Rey, Céline Auzanneau, Alban Bessede, Isabelle Soubeyran, Antoine Italiano

Trabectedin plus Durvalumab in Patients with Advanced Pretreated Soft Tissue Sarcoma and Ovarian Carcinoma (TRAMUNE)

12 / 29 / 2021

Trabectedin plus Durvalumab in Patients with Advanced Pretreated Soft Tissue Sarcoma and Ovarian Carcinoma (TRAMUNE)

Clinical cancer research, 2021, Dec 29
Maud Toulmonde, Mehdi Brahmi, Antoine Giraud, Camille Chakiba, Alban Bessede, Michèle Kind, Emilie Toulza, Marina Pulido, Sabrina Albert, Jean-Philippe Guégan, Sophie Cousin, Simone Mathoulin-Pelissier, Raul Perret, Sabrina Croce, Jean-Yves Blay, Isabelle Ray-Coquard, Anne Floquet, Antoine Italiano

Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1

08 / 20 / 2021

Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1

Nature Cancer, August 2021.

Lucile Vanhersecke, Maxime Brunet, Jean-Philippe Guégan, Christophe Rey, Antoine Bougouin, Sophie Cousin, Sylvestre Le Moulec, Benjamin Besse, Yohann Loriot, Mathieu Larroquette, Isabelle Soubeyran, Maud Toulmonde, Guilhem Roubaud, Simon Pernot, Mathilde Cabart, François Chomy, Corentin Lefevre, Kevin Bourcier, Michèle Kind, Ilenia Giglioli, Catherine Sautès-Fridman, Valérie Velasco, Félicie Courgeon, Ezoglin Oflazoglu, Ariel Savina, Aurélien Marabelle, Jean-Charles Soria, Carine Bellera, Casimir Sofeu, Alban Bessede, Wolf H. Fridman, François Le Loarer & Antoine Italiano.

Plasma proteomics identifies leukemia inhibitory factor (LIF) as a novel predictive biomarker

08 / 18 / 2021

Plasma proteomics identifies leukemia inhibitory factor (LIF) as a novel predictive biomarker

Plasma proteomics identifies leukemia inhibitory factor (LIF) as a novel predictive biomarker of immune-checkpoint blockade resistance
Annals of Oncology, 2021, Aug. 18.

Y Loriot, A Marabelle, J P Guégan, F X Danlos, B Besse, N Chaput, C Massard, D Planchard, C Robert, C Even, M Khettab, L Tselikas, L Friboulet, F André, I Nafia, F Le Loarer, J C Soria, A Bessede, A Italiano.