The study of cell migration in cancer research is of particular interest as two of the main challenges in the development of novel therapeutic strategies are i) the inhibition of metastatic progression of cancer cells and ii) stimulation of the recruitment of immune cells and their infiltration into the tumor masses. Indeed, while for cancer spread throughout the body cancer cells must migrate and invade through extracellular matrix, and intravasate/extravasate, chemotactic immune cell recruitment and infiltration into the tumor (e.g. neutrophils, effector T cells, regulatory T cells (Treg), Th17, macrophages, dendritic cells) is primordial for effective anti-tumor immune response to counter disease progression.
In this respect, Explicyte is offering valuable in vitro cell-based 96-w plate assays to evaluate compounds effects (with potential chemoattractive or chemorepulsive properties) on the migration of immune or cancer cells, respectively. Based on live cell time-lapse imaging, our assays unlike conventional single time-point chemotaxis/migration assays allow for full time course chemotaxis/cell migration profiles.