Specialty preclinical CRO services

Explicyte Immuno-Oncology

We test novel drugs in validated in vitro and in vivo tumor models of cancer immunotherapies and analyze the anti-tumor immune response.

In vitro screening
In vitro screening
Phenotypic screening & in vitro profiling in cancer cells co-cultured with PBMCs
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In vivo studies
In vivo studies
in vivo proof-of-concept studies in validated syngeneic mouse tumor models
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Biomarker analysis
Biomarker analysis
Immune biomarkers profiling in preclinical and clinical samples.
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Cancer immunotherapy Latest News

Explicyte immuno-oncology offers preclinical contract research services for cancer immunotherapy drug discovery. Our preclinical CRO services range from cell-based assays - for the phenotypic screening of novel immunotherapeutics and the in vitro determination of the molecular mechanism of action of new anti-cancer immune modulators - to in vivo studies, using syngeneic mouse tumor models treated with antitumor immunotherapies such as immune checkpoint inhibitors (anti CTLA-4  monoclonal antibodies, anti PD1/PDL-1 antibody  therapy and IDO/TDO inhibitors). Furthermore, we offer to explore the in vivo mechanism of action of innovative immunotherapies such as anti-cancer vaccines through the profiling of the anti-tumor immune response by flow cytometry, high-content imaging and RT-qPCR. All our drug development services for cancer immunotherapy are performed in Bordeaux, France. However, we routinely serve clients in the US, EU, UK, Germany and Switzerland.